We were called for SCIEX 5500 low sensitivity repair on an LC-MS system paired with an Agilent HPLC. The mass spectrometer was not delivering proper sensitivity, and the connected HPLC stack also needed testing and follow-up service to keep the full system operating correctly.

Diagnostics showed contamination in the front end of the mass spectrometer, affecting the ion source area and related front-end components. We cleaned the affected MS components, restored proper response, and completed tuning successfully with parameters meeting manufacturer requirements. During follow-up service, we also corrected a stuck ion spray capillary and performed additional front-end cleaning.

On the HPLC side, we carried out system testing, replaced routine wear components during preventive maintenance, and resolved an autosampler initialization failure by replacing the transport unit. We also repaired the degasser after finding a fault in the air pump and missing vacuum line components, then confirmed proper operation after repair.

A later pressure problem in the nitrogen generator was traced to multiple leaks and compressor sealing issues. After repairing the leaks, rebuilding the compressors, and completing full preventive maintenance on the generator, pressure was restored and the mass spectrometer completed normal startup. The LC-MS system was returned to stable working condition.